Found 64 matching trials
Alisertib in Treating Patients With Advanced or Metastatic Sarcoma
PHASE2This phase II trial studies how well alisertib works in treating patients w...
Location
Mayo Clinic in Arizona
Aurora A Kinase Inhibitor MLN8237 in Treating Patients With Unresectable Stage III-IV Melanoma
PHASE2RATIONALE: Aurora A kinase inhibitor MLN8237 may stop the growth of tumor c...
Location
Vanderbilt-Ingram Cancer Center
Alisertib in Chemotherapy-pretreated Urothelial Cancer
PHASE2Background:
Progress in developing new effective therapies in advanced and...
Location
Fondazione IRCCS Istituto Nazionale dei Tumori
Alisertib in Adults With Nonhematological Malignancies, Followed by Alisertib in Lung, Breast, Head and Neck or Gastroesophageal Malignancies
PHASE1This is an open-label, multicenter study with a phase 1 dose escalation por...
Location
Multiple Locations
MLN8237 to Treat Children With Relapsed/Refractory Solid Tumors
PHASE1RATIONALE: MLN8237 may stop the growth of cancer cells by blocking some of ...
Location
Multiple Locations
A Study of Alisertib (MLN8237) in Adult East Asian Participants With Advanced Solid Tumors or Lymphomas
PHASE1The purpose of this study was to determine the safety profile, maximum tole...
Location
National Cancer Centre
Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas
PHASE1This phase I trial studies the side effects and best dose of alisertib when...
Location
Sidney Kimmel Cancer Center at Thomas Jefferson University
A Phase 2 Trial of MLN8237 in Adult Participants With Acute Myelogenous Leukemia and High-Grade Myelodysplastic Syndrome
PHASE2This is an open-label, multicenter, phase 2 study of alisertib (MLN8237) in...
Location
Hematology and Oncology Associates of Northern New Jersey
Safety, Tolerability and Pharmacokinetic (PK) of Concomitant Esomeprazole and Rifampin, and QT Study on Single and Multiple-doses of Alisertib
PHASE1The purpose of this study is to assess the drug-drug interaction (DDI) of e...
Location
Multiple Locations
Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma
PHASE2Objectives:
Objectives
The primary objective of this study is to:
To ass...
Location
University of Texas MD Anderson Cancer Center